Hope for Depression Research Foundation

Hope for Depression Research Foundation

Non-profit Organizations

About Us

Hope for Depression Research Foundation (HDRF) is a 501(c) 3 non-profit founded by philanthropist Audrey Gruss in 2006 to spur cutting-edge neuroscience research into the origins, diagnosis, treatment and prevention of depression, a national public health crisis in the United States and the world's number one cause of disability and yet conventional medications today are outdated and do not fully work for 50% of patients. HDRF’s team of top brain scientists are transforming the treatment and prevention of depression when the world needs it most.

In 2010, HDRF formed the Depression Task Force, an outstanding collaboration leading neuroscientists from different universities who are pooling expertise and data to accelerate discovery. This team has discovered several new targets for treatment in the brain, and has a potential new class of medication in pilot clinical trials at Mount Sinai Medical Center, Columbia University, and Stanford University.

The mission of the HDRF is to spur innovative neuroscience research into the origins, medical diagnosis, new treatments, and prevention of depression and its related mood disorders - bipolar disorder, postpartum depression, post-traumatic stress disorder, anxiety disorder, and suicide. To date, HDRF has provided more than $50 million through over 200 grants for breakthrough depression research that promises to transform the way depression is viewed, diagnosed, treated, and prevented. In addition to research, HDRF aims to raise awareness of depression as a medical illness and to educate the public about the facts of depression.